Gt(ROSA)26Sortm2(MYC/ERT)Hsc
Targeted Allele Detail
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| Symbol: |
Gt(ROSA)26Sortm2(MYC/ERT)Hsc |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Hubert Schorle |
| MGI ID: |
MGI:5000147 |
| Synonyms: |
ROSAMER |
| Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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| Alliance: |
Gt(ROSA)26Sortm2(MYC/ERT)Hsc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:89756
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Conditional ready, Inducible, Inserted expressed sequence) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Gt(ROSA)26Sortm2(MYC/ERT)Hsc expresses
1 gene
Knock-in expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MYC (4609) |
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Mutation details: The knocked-in segment contains a splice acceptor, floxed neo STOP cassette, human MYC fused with ERT (a modified estrogen receptor rendered insensitive to estrogen but responsive to tamoxifen), and a polyadenylation sequence.
(J:89756)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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| Original: |
J:89756 Jager R, et al., Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Genesis. 2004 Mar;38(3):145-50 |
| All: |
1 reference(s) |
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Analysis Tools
