Col1a1tm2.1Bst
Targeted Allele Detail
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| Symbol: |
Col1a1tm2.1Bst |
| Name: |
collagen, type I, alpha 1; targeted mutation 2.1, Paul Bornstein |
| MGI ID: |
MGI:2178816 |
| Synonyms: |
exon 2delta |
| Gene: |
Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
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| Alliance: |
Col1a1tm2.1Bst page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:73906
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| Parent Cell Line: |
E14TG2a (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Intragenic deletion, Nucleotide substitutions
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Mutation details: A floxed PGK-neomycin resistance cassette deleted exon 2 and placed a silent mutation in exon 7. Cre-mediated recombination in vivo removed the neo cassette in the germ line. The authors predict that this allele would produce a correctly spliced protein that lacks 65 amino acids, almost the entire globular domain of the N-propeptide.
(J:73906)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Col1a1 Mutation: |
160 strains or lines available
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| Original: |
J:73906 Bornstein P, et al., The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. J Biol Chem. 2002 Jan 25;277(4):2605-13 |
| All: |
2 reference(s) |
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Analysis Tools
