Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plcg2al
Name:	phospholipase C, gamma 2; abnormal lymphatics
MGI ID:	MGI:3833399
Synonyms:	al
Gene:	Plcg2  Location: Chr8:118225030-118361881 bp, + strand  Genetic Position: Chr8, 64.26 cM
Alliance:	Plcg2al page

Strain of Origin:

129S/SvEv and C57BL/6J

Allele Type:    Spontaneous (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: It is a single A-to-G substitution located in exon 2 that resulted in a translational stop at amino acid 54 in the N-terminal pleckstrin homology domain of the gene. Absence of protein product was confirmed by Western blot analysis of newborn heart tissue lysates in homozygous mice. (J:143529) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcg2 Mutation:	74 strains or lines available

Original:	J:143529 Ichise H, et al., Phospholipase C{gamma}2 is necessary for separation of blood and lymphatic vasculature in mice. Development. 2009 Jan;136(2):191-5
All:	1 reference(s)