Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Slc6a4tm1Kpl
Name:	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; targeted mutation 1, Klaus-Peter Lesch
MGI ID:	MGI:2178613
Synonyms:	5-HTT-, 5-HTT KO, SERT -
Gene:	Slc6a4  Location: Chr11:76889429-76923166 bp, + strand  Genetic Position: Chr11, 46.18 cM
Alliance:	Slc6a4tm1Kpl page

Germline Transmission:	Earliest citation of germline transmission: J:76020
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a DNA segment containing exon 2. Binding assays on brain sections of adult homozygous mice confirmed that no functional protein was expressed from this allele. (J:76020)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Slc6a4 Mutation:	51 strains or lines available

Original:	J:76020 Bengel D, et al., Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol. 1998 Apr;53(4):649-55
All:	160 reference(s)