Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hdac3tm1.1Eno
Name:	histone deacetylase 3; targeted mutation 1.1, Eric N Olson
MGI ID:	MGI:3831693
Synonyms:	Hdac3loxP
Gene:	Hdac3  Location: Chr18:38070024-38088073 bp, - strand  Genetic Position: Chr18, 19.81 cM, cytoband B3
Alliance:	Hdac3tm1.1Eno page

Germline Transmission:	Earliest citation of germline transmission: J:144604
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted in intron 10 and an frt flanked neomycin selection as well as a second loxP site were placed in intron 14. The neomycin cassette was subsequently removed by crossing to FLPe transgenic mice which leaves exons 11-14 flanked by loxP. (J:144604)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac3 Mutation:	31 strains or lines available

Original:	J:144604 Montgomery RL, et al., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest. 2008 Nov;118(11):3588-97
All:	13 reference(s)