Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tph2tm1Lex
Name:	tryptophan hydroxylase 2; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:3831654
Gene:	Tph2  Location: Chr10:114914546-115020927 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Tph2tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:144582
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Exons 1 and 2 were replaced with a neo cassette. (J:144582)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:	41 strains or lines available

Original:	J:144582 Savelieva KV, et al., Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008;3(10):e3301
All:	4 reference(s)