Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptentm1Rdp
Name:	phosphatase and tensin homolog; targeted mutation 1, Ronald DePinho
MGI ID:	MGI:3831201
Synonyms:	PtenL, Ptenlox, Ptenlox5
Gene:	Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance:	Ptentm1Rdp page

Germline Transmission:	Earliest citation of germline transmission: J:140704
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:140704)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Ptentm1Rdp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	81 strains or lines available

Original:	J:140704 Zheng H, et al., p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Oct 23;455(7216):1129-33
All:	47 reference(s)