Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(DTA)Lky
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Richard M Locksley
MGI ID:	MGI:3829362
Synonyms:	R-DTA, ROSA-DTA
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(DTA)Lky page

Germline Transmission:	Earliest citation of germline transmission: J:133382
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change) Mutation:    Insertion   Mutation details: A floxed neo/STOP cassette and DTA (diphtheria toxin alpha chain) gene were inserted into the locus. Expression of DTA is only achieved following cre-mediated removal of the floxed neo/STOP cassette. (J:133382)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

44 assay results

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(DTA)Lky

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:133382 Voehringer D, et al., Homeostasis and effector function of lymphopenia-induced 'memory-like' T cells in constitutively T cell-depleted mice. J Immunol. 2008 Apr 1;180(7):4742-53
All:	194 reference(s)