Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cc2d1atm1Zjc
Name:	coiled-coil and C2 domain containing 1A; targeted mutation 1, Zhijian Chen
MGI ID:	MGI:3829256
Synonyms:	1AKO-A, Mit5-
Gene:	Cc2d1a  Location: Chr8:84859457-84874546 bp, - strand  Genetic Position: Chr8, 40.32 cM
Alliance:	Cc2d1atm1Zjc page

Germline Transmission:	Earliest citation of germline transmission: J:177407
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector containing a beta galactosidase gene (lacZ), followed by a loxP-flanked neomycin resistance cassette was fused in-frame to exon 1. The tergeting vector deleted exons 1-10 (amino acids 3-349) of the gene. Southern and Western blot failed to detect DNA or protein, respectively, in mutants. (J:177407)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cc2d1a Mutation:	32 strains or lines available

Original:	J:177407 Zhao M, et al., Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses. J Neurophysiol. 2011 Apr;105(4):1506-15
All:	3 reference(s)