Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hrastm1Tyj
Name:	Harvey rat sarcoma virus oncogene; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:3829071
Synonyms:	Hras LSL G12D
Gene:	Hras  Location: Chr7:140770839-140773938 bp, - strand  Genetic Position: Chr7, 86.48 cM
Alliance:	Hrastm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:163152
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A G12D mutation was introduced to the targeted gene along with a reverse orientation lox-stop/puromycin resistance-lox cassette placed in intron 1. The G12D mutant form of protein is conditionally expressed from this gene when a floxed stop segment is excised by Cre. (J:163152)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hras Mutation:	30 strains or lines available

Original:	J:163152 Jacks T, Direct Data Submission for Hras1 allele. MGI Direct Data Submission. 2010;
All:	2 reference(s)