Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Htr2ctm2Knk
Name:	5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 2, Kazuko Nishikura
MGI ID:	MGI:3823042
Synonyms:	5-HT2CR-INI
Gene:	Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance:	Htr2ctm2Knk page

Germline Transmission:	Earliest citation of germline transmission: J:142503
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Not Applicable) Mutation:    Intragenic deletion   Mutation details: The editing complimentary sequence in intron 5 was deleted to block RNA editing of adenosine to inosine at positions 156, 158 and 160. Mice only express the isoform carrying I156, N158, and I160 (INI). (J:142503)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:	12 strains or lines available

Original:	J:142503 Kawahara Y, et al., Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass. J Neurosci. 2008 Nov 26;28(48):12834-44
All:	2 reference(s)