Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdx1tm1Lhn
Name:	caudal type homeobox 1; targeted mutation 1, David Lohnes
MGI ID:	MGI:3817874
Synonyms:	Cdx1-rare-, RARE
Gene:	Cdx1  Location: Chr18:61151934-61169271 bp, - strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Cdx1tm1Lhn page

Germline Transmission:	Earliest citation of germline transmission: J:86514
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A retinoic acid response element (RARE) lies about 1-kb upstream from the coding sequence of the gene. The response element was replaced by a floxed neo cassette. Chimeric males bearing the targeted allele were crossed with transgenic mice expressing cre-recombinase to remove the neo-cassette. Whole-mount in situ hybridization revealed reduced expression of the gene locus during embryonic development including in the primitive streak phase and during formation of the neuroectoderm. (J:86514)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdx1 Mutation:	13 strains or lines available

Original:	J:86514 Houle M, et al., Retinoic acid regulates a subset of Cdx1 function in vivo. Development. 2003 Dec;130(26):6555-67
All:	1 reference(s)