Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Six3tm3.1Gco
Name:	sine oculis-related homeobox 3; targeted mutation 3.1, Guillermo Oliver
MGI ID:	MGI:3814870
Synonyms:	Six3ki
Gene:	Six3  Location: Chr17:85921036-85933619 bp, + strand  Genetic Position: Chr17, 55.42 cM
Alliance:	Six3tm3.1Gco page

Germline Transmission:	Earliest citation of germline transmission: J:140315
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted Mutation:    Insertion   Mutation details: This allele was produced from Six3tm3Gco by germline expression of Foxg1tm1(cre)Skm which results in excision of the 5' stop codon and its associated selection cassette. (J:140315)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:	13 strains or lines available

Original:	J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
All:	1 reference(s)