Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gcktm1.2Mgn
Name:	glucokinase; targeted mutation 1.2, Mark A Magnuson
MGI ID:	MGI:2177710
Synonyms:	gkdel
Gene:	Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance:	Gcktm1.2Mgn page

Germline Transmission:	Earliest citation of germline transmission: J:51826
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele is a derivative of Gcktm1Mgn in which all the loxP flanked sequences including exons 9 and 10 as well as the neomycin selection cassette were deleted by injecting heterozygous fertilized eggs with a plasmid expressing Cre recombinase. Progeny were screened for the allele in which all sequences were deleted. (J:51826)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:	59 strains or lines available

Original:	J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:	2 reference(s)