Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-1tm3Rdl
Name:	NK2 homeobox 1; targeted mutation 3, Roberto Di Lauro
MGI ID:	MGI:4941952
Synonyms:	Nkx2-1deltaCOOH
Gene:	Nkx2-1  Location: Chr12:56578741-56583570 bp, - strand  Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
Alliance:	Nkx2-1tm3Rdl page

Germline Transmission:	Earliest citation of germline transmission: J:169693
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' coding region was removed and a neo cassette was inserted downstream of the coding region. The predicted protein product lacks the C-terminal amino acids (221-372). (J:169693)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-1 Mutation:	24 strains or lines available

Original:	J:169693 Silberschmidt D, et al., In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1. BMC Dev Biol. 2011;11:9
All:	1 reference(s)