Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dicer1tm1.1Snj
Name:	dicer 1, ribonuclease type III; targeted mutation 1.1, Stephen N Jones
MGI ID:	MGI:3809262
Synonyms:	DicerdeltaC
Gene:	Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance:	Dicer1tm1.1Snj page

Germline Transmission:	Earliest citation of germline transmission: J:139257
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Cre recombination in ES cells was used to remove exons 15 through 17, which encode the PAZ domain. (J:139257)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:	94 strains or lines available

Original:	J:139257 Mudhasani R, et al., Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30;181(7):1055-63
All:	2 reference(s)