Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hprt1tm4(ROBO4*-lacZ)Aird
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, William C Aird
MGI ID:	MGI:3808842
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm4(ROBO4*-lacZ)Aird page

Germline Transmission:	Earliest citation of germline transmission: J:138735
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: A human ROBO4 promoter with a mutated ETS site at -119 was used to drive expression of a lacZ gene inserted upstream of the endogenous Hprt locus. Details are not provided. Tissue expression was reduced. (J:138735)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1274 strains or lines available

Original:	J:138735 Okada Y, et al., A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood. 2008 Sep 15;112(6):2336-9
All:	1 reference(s)