Lmnatm8Lgf
Targeted Allele Detail
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| Symbol: |
Lmnatm8Lgf |
| Name: |
lamin A; targeted mutation 8, Loren G Fong |
| MGI ID: |
MGI:4868581 |
| Synonyms: |
LmnacsmHG |
| Gene: |
Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
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| Alliance: |
Lmnatm8Lgf page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:167229
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 10, 11, and 12 (and the introns between) were replaced with the corresponding cDNA sequence in which the last 150 bp of exon 11 were removed as well as 3 nucleotides of exon 12 that code for the isoleucine in the C-terminal CSIM sequence. A floxed neo cassette was inserted downstream of exon 12. This allele is predicted to produce a non-farnesylated protein because it lacks the farnesylatible isoleucine in the CaaX motif. The absence of A and C isoforms and production of the progerin isoform was confirmed by western blot analysis on liver extracts.
(J:167229)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Lmna Mutation: |
82 strains or lines available
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| Original: |
J:167229 Yang SH, et al., Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. Hum Mol Genet. 2011 Feb 1;20(3):436-44 |
| All: |
2 reference(s) |
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Analysis Tools
