Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkd1tm1.1Daca
Name:	protein kinase D1; targeted mutation 1.1, Doreen A Cantrell
MGI ID:	MGI:4867731
Synonyms:	PKD1(S744A/S748A), Prkd1SSAA
Gene:	Prkd1  Location: Chr12:50388014-50695881 bp, - strand  Genetic Position: Chr12, 21.78 cM, cytoband C1
Alliance:	Prkd1tm1.1Daca page

Germline Transmission:	Earliest citation of germline transmission: J:166867
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 17 was replaced with a modified one in which nucleotide substitution results in the amino acid substitution of alanine for serine at positions 744 and 748 (S744A, S748A). A floxed neo cassette inserted downstream of the modified exon 17 was removed by cre-mediated recombination. (J:166867)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkd1 Mutation:	55 strains or lines available

Original:	J:166867 Matthews SA, et al., Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells. Biochem J. 2010 Oct 25;432(1):153-63
All:	3 reference(s)