Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hrm1Btlr
Name:	lysine demethylase and nuclear receptor corepressor; mutation 1, Bruce Beutler
MGI ID:	MGI:3805975
Synonyms:	prune
Gene:	Hr  Location: Chr14:70789652-70810988 bp, + strand  Genetic Position: Chr14, 36.32 cM
Alliance:	Hrm1Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The prune mutation, discovered among G3 progeny of an ENU-mutagenized male mouse, corresponds to a T-to-G transversion at nucleotide position 3938 of the gene (Genbank: NM__021877), in exon 18 of 20 total exons. It results in replacement of a highly-conserved tyrosine by aspartic acid at amino acid 1082 of the protein (Y1082D). (J:138686) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hr Mutation:	84 strains or lines available

Original:	J:138686 Siggs OM, et al., Record for "prune", updated 2nd of September, 2008. MGI Direct Data Submission. 2008;
All:	1 reference(s)