About   Help   FAQ
Lyl1tm1e(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Lyl1tm1e(EUCOMM)Hmgu
Name: lymphoblastomic leukemia 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4841781
Gene: Lyl1  Location: Chr8:85428078-85431569 bp, + strand  Genetic Position: Chr8, 41.02 cM
Mutation
origin
Mutant Cell Lines:  HEPD0669_7_A05, HEPD0669_7_A06, HEPD0669_7_A07, HEPD0669_7_B06, HEPD0669_7_B07, HEPD0669_7_C06, HEPD0669_7_D05, HEPD0669_7_D06, HEPD0669_7_E05, HEPD0669_7_E06, HEPD0669_7_E07, HEPD0669_7_E08, HEPD0669_7_H08
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 85428883 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Lyl1 Mutation:  5 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/05/2021
MGI 6.17
The Jackson Laboratory