Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Mapk1tm1Gela
Name:	mitogen-activated protein kinase 1; targeted mutation 1, Gary E Landreth
MGI ID:	MGI:3803954
Synonyms:	ERK2fl, Mapk1flox
Gene:	Mapk1  Location: Chr16:16801246-16865317 bp, + strand  Genetic Position: Chr16, 10.53 cM
Alliance:	Mapk1tm1Gela page

Germline Transmission:	Earliest citation of germline transmission: J:137882
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Transient cre transfection into ES cells was used to remove the neo cassette leaving exon 2 floxed. (J:137882)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

List all tumor models in MMHCdb carrying Mapk1tm1Gela

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:	40 strains or lines available

Original:	J:137882 Samuels IS, et al., Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 Jul 2;28(27):6983-95
All:	40 reference(s)