Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Sox3tm1Lja
Name:	SRY (sex determining region Y)-box 3; targeted mutation 1, J Larry Jameson
MGI ID:	MGI:4839476
Gene:	Sox3  Location: ChrX:59934972-59937036 bp, - strand  Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
Alliance:	Sox3tm1Lja page

Germline Transmission:	Earliest citation of germline transmission: J:86431
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector for this single exon gene was designed to place an upstream loxP site in the 5' untranslated region. The downstream loxP site was inserted downstream of the polyA signal sequences and a neomycin cassette. (J:86431)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sox3 Mutation:	7 strains or lines available

Original:	J:86431 Weiss J, et al., Sox3 is required for gonadal function, but not sex determination, in males and females. Mol Cell Biol. 2003 Nov;23(22):8084-91
All:	1 reference(s)