Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nlrp3m2Btlr
Name:	NLR family, pyrin domain containing 3; mutation 2, Bruce Beutler
MGI ID:	MGI:4835549
Synonyms:	ND5
Gene:	Nlrp3  Location: Chr11:59432395-59457781 bp, + strand  Genetic Position: Chr11, 37.73 cM, cytoband B1.3
Alliance:	Nlrp3m2Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The ND5 mutation corresponds to a T to C transition at position 3092 of the transcript, in exon 9 of 10 total exons (Genbank record NM_145827). The mutation is located in the eighth coding exon and causes a tryptophan to arginine substitution at amino acid 956 of the protein. (J:164865)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp3 Mutation:	61 strains or lines available

Original:	J:164865 Beutler B, ND5 is an allele of Nlrp3 and causes reduced macrophage IL-1beta response to LPS and nigericin. MGI Direct Data Submission. 2010;
All:	2 reference(s)