Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smad4tm1.1Rdp
Name:	SMAD family member 4; targeted mutation 1.1, Ronald DePinho
MGI ID:	MGI:4830314
Synonyms:	Smad4-
Gene:	Smad4  Location: Chr18:73772080-73836851 bp, - strand  Genetic Position: Chr18, 49.51 cM
Alliance:	Smad4tm1.1Rdp page

Germline Transmission:	Earliest citation of germline transmission: J:163858
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     LoxP sites were inserted to flank exons 8 and 9. Cre mediated recombination removed exons 8 and 9. (J:116139)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:	43 strains or lines available

Original:	J:163858 Morsut L, et al., Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 1;137(15):2571-8
All:	3 reference(s)