Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm5(phiC31)Sor
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Philippe Soriano
MGI ID:	MGI:4829675
Synonyms:	phiC31
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm5(phiC31)Sor page

Germline Transmission:	Earliest citation of germline transmission: J:128069
Parent Cell Line:	AK7.1 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gt(ROSA)26Sortm5(phiC31)Sor expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gt(ROSA)26Sor (MGI:104735)   Mutation details: A targeting construct with the SA-PhiC31opA-PGKneopA cassette, which contains the site-specific recombinase PhiC31 sequence (with a C-terminal SV40 nuclear localization signal) driven by the phosphoglycerate kinase 1 (PGK) promoter, and bovine growth hormone polyadenylation (bpA) sequence was inserted into the Gt(ROSA)26Sor locus. PhiC31-mediated recombination in mice carrying containing a sequence of interest flanked by attB and attP sites results in tissue-specific deletion of the targeted sequence. (J:128069)

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:128069 Raymond CS, et al., High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells. PLoS One. 2007;2(1):e162
All:	2 reference(s)