Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mef2ctm1(KOMP)Mbp
Name:	myocyte enhancer factor 2C; targeted mutation 1, Mouse Biology Program, UC Davis
MGI ID:	MGI:4819977
Gene:	Mef2c  Location: Chr13:83652153-83815199 bp, + strand  Genetic Position: Chr13, 43.68 cM
Alliance:	Mef2ctm1(KOMP)Mbp page
IMPC:	Mef2c gene page

Mutant Cell Lines:	DEPD00527_3_A03, DEPD00527_3_B02, DEPD00527_3_B03, DEPD00527_3_B04, DEPD00527_3_C02, DEPD00527_3_C03, DEPD00527_3_D01, DEPD00527_3_D03, DEPD00527_3_D04, DEPD00527_3_E03, DEPD00527_3_F02, DEPD00527_3_H01, DEPD00527_3_H04
Germline Transmission:	Earliest citation of germline transmission: J:188991
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 654 starting at position 83740572 and ending at position 83741226 of Chromosome 13 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Mef2c Mutation:	33 strains or lines available

Original:	J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:	2 reference(s)