Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oxtrtm1Wsy
Name:	oxytocin receptor; targeted mutation 1, W Scott Young III
MGI ID:	MGI:3800795
Synonyms:	OxtrNeo
Gene:	Oxtr  Location: Chr6:112450644-112466904 bp, - strand  Genetic Position: Chr6, 52.27 cM, cytoband E3
Alliance:	Oxtrtm1Wsy page

Germline Transmission:	Earliest citation of germline transmission: J:137445
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted downstream of exon 3. Autoradiography with 125-I labeled ornithine vasotocin, an Oxt antagonist, confirmed decreased endogenous and ectopic protein expression. (J:137445)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxtr Mutation:	40 strains or lines available

Original:	J:137445 Lee HJ, et al., A conditional knockout mouse line of the oxytocin receptor. Endocrinology. 2008 Jul;149(7):3256-63
All:	2 reference(s)