Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Clcn5tm3.1Tjj
Name:	chloride channel, voltage-sensitive 5; targeted mutation 3.1, Thomas J Jentsch
MGI ID:	MGI:4457505
Synonyms:	Clcn5*
Gene:	Clcn5  Location: ChrX:7020049-7185597 bp, - strand  Genetic Position: ChrX, 3.21 cM, cytoband F3-F4
Alliance:	Clcn5tm3.1Tjj page

Germline Transmission:	Earliest citation of germline transmission: J:160701
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: Exon 12 was replaced with one containing nucleotide substitutions that result in the amino acid substitutions of alanine for aspartic acid and methionine for lysine. An frt flanked neo cassette inserted upstream of exon 12 was removed by flp mediated recombination. These substitutions convert the C-terminus to that of Clcn3. (J:160701)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn5 Mutation:	16 strains or lines available

Original:	J:160701 Novarino G, et al., Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis. Science. 2010 Jun 11;328(5984):1398-401
All:	1 reference(s)