Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tektm1Dmt
Name:	TEK receptor tyrosine kinase; targeted mutation 1, Daniel J Dumont
MGI ID:	MGI:2159357
Synonyms:	tekdeltasp, Tie2-
Gene:	Tek  Location: Chr4:94627526-94763213 bp, + strand  Genetic Position: Chr4, 43.34 cM
Alliance:	Tektm1Dmt page

Germline Transmission:	Earliest citation of germline transmission: J:20015
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced sequences in exon 1, which encode the translation start site and the first 17 amino acids of the protein. (J:20015)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tek Mutation:	92 strains or lines available

Original:	J:20015 Dumont DJ, et al., Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 1994 Aug 15;8(16):1897-909
All:	13 reference(s)