Cyp11a1tm1(GFP/cre)Pzg
Targeted Allele Detail
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Symbol: |
Cyp11a1tm1(GFP/cre)Pzg |
Name: |
cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 1, Pumin Zhang |
MGI ID: |
MGI:4442187 |
Synonyms: |
Cyp11a1-GFP-Cre, Cyp11a1tm1(GFP/cre)Zhang |
Gene: |
Cyp11a1 Location: Chr9:57913694-57934306 bp, + strand Genetic Position: Chr9, 31.63 cM
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Alliance: |
Cyp11a1tm1(GFP/cre)Pzg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:159099
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Parent Cell Line: |
E14TG2a.4 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Cyp11a1tm1(GFP/cre)Pzg expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Cyp11a1 (MGI:88582) |
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Mutation details: A targeting vector containing a GFP-Cre cassette (GC) and a FRT site-flanked kanamycin and neomycin resistance cassette was inserted into the first coding exon of the endogenous gene immediately following the ATG translation initiation codon. Although no green fluorescence is visible in whole heterozygous mutant E15.5 embryos or their urogenital tracts, immunohistochemical analysis detects GFP protein in their kidneys and testes. In E15.5 embryos bearing this allele and a Cre recombinase-inducible lacZ reporter gene, beta-galactosidase activity is detected by X-gal staining in kidneys and adrenals of both sexes and in testes.
(J:159099)
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Inheritance: |
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Not Specified |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Cyp11a1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010; |
All: |
7 reference(s) |
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