Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Acadstm1a(EUCOMM)Hmgu
Name:	acyl-Coenzyme A dehydrogenase, short chain; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4436588
Gene:	Acads  Location: Chr5:115248358-115257405 bp, - strand  Genetic Position: Chr5, 55.99 cM
IMPC:	Acads gene page

Mutant Cell Line:	HEPD0517_2_D08
Germline Transmission:	Unknown
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_gt1   Mutation details: The L1L2_gt1 cassette was inserted at position 115255335 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 115256333. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Acads Mutation:	24 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)