Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hiratm1Aam
Name:	histone cell cycle regulator; targeted mutation 1, Alea A Mills
MGI ID:	MGI:3798961
Gene:	Hira  Location: Chr16:18695787-18789059 bp, + strand  Genetic Position: Chr16, 11.69 cM, cytoband A-B1
Alliance:	Hiratm1Aam page

Germline Transmission:	Earliest citation of germline transmission: J:136969
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exons 3 to 9 of the Hprt gene along with a 5' loxP site and puromycin resistance cassette were inserted into the coding region, to create the endpoint for a 1.3 Mb deletion syntenic to a 1.5 Mb deletion found in chromosome 22 deletion syndrome patients. (J:136969)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hira Mutation:	74 strains or lines available

Original:	J:136969 Stark KL, et al., Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60
All:	1 reference(s)