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Sp7tm1e(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Sp7tm1e(EUCOMM)Hmgu
Name: Sp7 transcription factor 7; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:4435297
Gene: Sp7  Location: Chr15:102356603-102367035 bp, - strand  Genetic Position: Chr15, 57.51 cM
Mutation
origin
Mutant Cell Lines:  HEPD0529_3_A09, HEPD0529_3_A11, HEPD0529_3_C09, HEPD0529_3_C12, HEPD0529_3_D09, HEPD0529_3_D11, HEPD0529_3_E11, HEPD0529_3_F09, HEPD0529_3_G09, HEPD0529_3_G11, HEPD0529_3_H10
Germline Transmission:  Unknown
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Pgk_P
 
Mutation detailsThe L1L2_Pgk_P cassette was inserted at position 102359837 of Chromosome 15 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Sp7 Mutation:  7 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2021
MGI 6.16
The Jackson Laboratory