Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Faim2tm1a(EUCOMM)Hmgu
Name:	Fas apoptotic inhibitory molecule 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:4434707
Gene:	Faim2  Location: Chr15:99394893-99426046 bp, - strand  Genetic Position: Chr15, 56.13 cM, cytoband F3
IMPC:	Faim2 gene page

Mutant Cell Lines:	HEPD0529_2_A09, HEPD0529_2_B11, HEPD0529_2_C09, HEPD0529_2_C11, HEPD0529_2_E09, HEPD0529_2_E10, HEPD0529_2_E11, HEPD0529_2_G11, HEPD0529_2_H09
Germline Transmission:	Unknown
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Pgk_P   Mutation details: The L1L2_Pgk_P cassette was inserted at position 99417940 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 99419592. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Faim2 Mutation:	22 strains or lines available

Original:	J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:	1 reference(s)