Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Timp3tm1Hest
Name:	tissue inhibitor of metalloproteinase 3; targeted mutation 1, Heidi Stohr
MGI ID:	MGI:3797605
Gene:	Timp3  Location: Chr10:86136276-86185369 bp, + strand  Genetic Position: Chr10, 42.83 cM, cytoband C1-D1
Alliance:	Timp3tm1Hest page

Germline Transmission:	Earliest citation of germline transmission: J:136890
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neo cassette was inserted into exon 3 leading to a frame shift and the introduction of a premature stop codon. The absence of protein product was confirmed by western blot analysis on primary fibroblast extracts. (J:136890)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Timp3 Mutation:	18 strains or lines available

Original:	J:136890 Janssen A, et al., Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2812-22
All:	4 reference(s)