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Clk1tm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Clk1tm1a(EUCOMM)Wtsi
Name: CDC-like kinase 1; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4432186
Gene: Clk1  Location: Chr1:58411988-58424088 bp, - strand  Genetic Position: Chr1, 29.09 cM
Mutation
origin
Mutant Cell Lines:  EPD0065_2_A05, EPD0065_2_A06, EPD0065_2_B04, EPD0065_2_B05, EPD0065_2_C05, EPD0065_2_C06, EPD0065_2_D04, EPD0065_2_D05, EPD0065_2_D06, EPD0065_2_E04, EPD0065_2_E06, EPD0065_2_F04, EPD0065_2_F05, EPD0065_2_G04, EPD0065_2_G05, EPD0065_2_G06, EPD0065_2_H04, EPD0065_2_H05
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8.F6 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 58417865 of Chromosome 1 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 58416760. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Clk1 Mutation:  29 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory