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Phykpltm1a(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Phykpltm1a(EUCOMM)Wtsi
Name: 5-phosphohydroxy-L-lysine phospholyase; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4431628
Gene: Phykpl  Location: Chr11:51584540-51603271 bp, + strand  Genetic Position: Chr11, 31.08 cM, cytoband B1.3
Mutation
origin
Mutant Cell Lines:  EPD0021_1_A04, EPD0021_1_A05, EPD0021_1_D04, EPD0021_1_D05, EPD0021_1_E04, EPD0021_1_E05, EPD0021_1_E06, EPD0021_1_F05, EPD0021_1_G04, EPD0021_1_G05, EPD0021_1_G06, EPD0021_1_H04, EPD0021_1_H05, EPD0021_1_H06
Germline Transmission:  Earliest citation of germline transmission: J:165965
Parent Cell Line:  JM8 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt2
 
Mutation detailsThe L1L2_gt2 cassette was inserted at position 51585261 of Chromosome 11 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 51585859. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:155845, J:173534)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Phykpl Mutation:  19 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory