Foxp3tm6.1Ayr
Targeted Allele Detail
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Symbol: |
Foxp3tm6.1Ayr |
Name: |
forkhead box P3; targeted mutation 6.1, Alexander Y Rudensky |
MGI ID: |
MGI:4430226 |
Synonyms: |
Foxp3floxedCNS2gfp |
Gene: |
Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
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Alliance: |
Foxp3tm6.1Ayr page
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Allele Type: |
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Targeted (Conditional ready, Modified regulatory region, No functional change) |
Mutation: |
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Insertion
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Mutation details: Two loxP sequences flanking conserved non-coding sequence 2 (CNS2 (Rr124)) in intron 1, as well as an FRT site flanked neomycin resistance gene cassette were inserted by homologous recombination. In addition, an EGFP cassette was inserted in-frame into the first coding exon. The selection cassette was removed by flp-mediated recombination.
(J:156942)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxp3 Mutation: |
55 strains or lines available
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Original: |
J:156942 Zheng Y, et al., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature. 2010 Feb 11;463(7282):808-12 |
All: |
2 reference(s) |
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