Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Foxl2tm4(cre)Tre
Name:	forkhead box L2; targeted mutation 4, Mathias Treier
MGI ID:	MGI:4430207
Synonyms:	Foxl2Cre
Gene:	Foxl2  Location: Chr9:98837660-98840179 bp, + strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance:	Foxl2tm4(cre)Tre page

Germline Transmission:	Earliest citation of germline transmission: J:157008
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Foxl2tm4(cre)Tre expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Foxl2 (MGI:1349428)   Mutation details: A 1.6 kb fragment encoding cre recombinase followed by the rabbit beta-globin polyadenylation signal was used to generate a targeting vector that replaced the translational start site of Foxl2 with the cre-ATG start codon by homologous recombination. The targeting vector contained a self-excising neo cassette (ACN cassette) and a diphtheria toxin-negative selection cassette (DTA). The ACN cassette was excised during passage through the male germline. (J:157008)

Activity:	Tissue activity of this recombinase allele
Driver:	Foxl2 (mouse) Summary of all recombinase alleles driven by Foxl2. Alliance mouse Foxl2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxl2 Mutation:	15 strains or lines available

Original:	J:157008 Uhlenhaut NH, et al., Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. Cell. 2009 Dec 11;139(6):1130-42
All:	2 reference(s)