Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Atoh1tm5.1(cre/PGR)Hzo
Name:	atonal bHLH transcription factor 1; targeted mutation 5.1, Huda Y Zoghbi
MGI ID:	MGI:4418334
Synonyms:	Atoh1tm5Hzo, Math1cre*PR
Gene:	Atoh1  Location: Chr6:64706109-64708229 bp, + strand  Genetic Position: Chr6, 30.03 cM
Alliance:	Atoh1tm5.1(cre/PGR)Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:155760
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    mifepristone Mutations:    Insertion, Intragenic deletion   Atoh1tm5.1(cre/PGR)Hzo expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Atoh1 (MGI:104654)   Mutation details: All coding sequence was replaced by a modified cre/progesterone receptor fusion construct followed by an frt flanked PGK-neomycin selection cassette. The selection cassette was subsequently excised by crossing to mice carrying Gt(ROSA)26Sortm1(FLP1)Dym. In the resulting mice, the inducible cre is under the control of the endogenous gene promoter. (J:155932)

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Alliance mouse Atoh1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atoh1 Mutation:	36 strains or lines available

Original:	J:155760 Rose MF, et al., Math1 is essential for the development of hindbrain neurons critical for perinatal breathing. Neuron. 2009 Nov 12;64(3):341-54
All:	9 reference(s)