Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hes1tm1(cre/ERT2)Lcm
Name:	hes family bHLH transcription factor 1; targeted mutation 1, L Charles Murtaugh
MGI ID:	MGI:4412375
Synonyms:	Hes1C2, Hes1CF, Hes1CreERT2
Gene:	Hes1  Location: Chr16:29883259-29886614 bp, + strand  Genetic Position: Chr16, 21.09 cM
Alliance:	Hes1tm1(cre/ERT2)Lcm page

Germline Transmission:	Earliest citation of germline transmission: J:154982
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Hes1tm1(cre/ERT2)Lcm expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hes1 (MGI:104853)   Mutation details: A targeting vector generated by bacterial recombineering replaced most of the Hes1 open reading from with a cre/ERT2 sequence linked to an Frt-flanked neomycin resistance cassette. Following homologous recombination in R1 ES cells, germline chimeras were generated and subsequently the neo cassette was excised in vivo by crossing mutants to Gt(ROSA)26Sortm1(FLP1)Dym mice. (J:154982, J:169830)

Activity:	Tissue activity of this recombinase allele
Driver:	Hes1 (mouse) Summary of all recombinase alleles driven by Hes1. Comparative matrix view of recombinase activities Alliance mouse Hes1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hes1 Mutation:	21 strains or lines available

Original:	J:154982 Yun S, et al., Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
All:	10 reference(s)