Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Scn10aPsm Name: sodium channel, voltage-gated, type X, alpha; possum MGI ID: MGI:3794859 Synonyms: Nav1.8Possum, Scn10am1Btlr Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal Alliance: Scn10aPsm page

Scn10aPsm/Scn10aPsm mice display inducible immobility Show the 1 phenotype image(s) involving this allele.

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: An A-to-G transition at nucleotide position 2403 of the gene (Genbank Accession NM_009134) results in replacement of threonine by alanine at amino acid position 790 of the Nav1.8 protein. This mutation produces a dominant hypermorph. (J:180381) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:	102 strains or lines available

Original:	J:180381 Blasius AL, et al., Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19413-8
All:	2 reference(s)