Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Cdc73Gt(RRE190)Byg
Name:	cell division cycle 73, Paf1/RNA polymerase II complex component; gene trap RRE190, BayGenomics
MGI ID:	MGI:3794028
Synonyms:	Hrpt2-
Gene:	Cdc73  Location: Chr1:143479014-143578631 bp, - strand  Genetic Position: Chr1, 62.52 cM
Alliance:	Cdc73Gt(RRE190)Byg page

Mutant Cell Line:	RRE190
Germline Transmission:	Earliest citation of germline transmission: J:135255
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Gene trapped (Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT2Lxf     Vector Type: gene trap   Mutation details: The gene trap vector containing a beta-geo cassette was inserted downstream of exon 6. The resulting fusion protein lacks the 361 carboxy terminal amino acids. This is a reporter allele and a gene trapped allele. (J:135255) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select RRE190 CC249591 (MGI Seq Detail) 5' RACE Chr1:143561662-143578324 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 26 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdc73Gt(RRE190)Byg

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc73 Mutation:	45 strains or lines available

Original:	J:135255 Wang P, et al., Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol. 2008 May;28(9):2930-40
All:	3 reference(s)