Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx21duane
Name:	T-box 21; Duane
MGI ID:	MGI:4367995
Synonyms:	Tbx21du
Gene:	Tbx21  Location: Chr11:96988897-97006157 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Alliance:	Tbx21duane page

Strain of Origin:	C57BL/6
Project Collection:	APF ENU Mutagenesis

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis induced a point mutation (T to A chr 11: 96973058) in the second intron altering the splice acceptor site and thereby preventing normal splicing. This mutation deletes 8 amino acids from the final peptide. Activated splenocytes exhibit a 3- to 4-fold decrease in protein expression compared with similarly treated wild-type cells. (J:154069) Inheritance:    Recessive

Location of the Tbx21duane mutation

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:	36 strains or lines available

Original:	J:154069 Jenne CN, et al., T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009 Oct 26;206(11):2469-81
All:	3 reference(s)