Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Tnnt3tm2a(KOMP)Wtsi Name: troponin T3, skeletal, fast; targeted mutation 2a, Wellcome Trust Sanger Institute MGI ID: MGI:4363809 Synonyms: Tnnt3lacZ Gene: Tnnt3  Location: Chr7:142052573-142069746 bp, + strand  Genetic Position: Chr7, 87.94 cM Alliance: Tnnt3tm2a(KOMP)Wtsi page IMPC: Tnnt3 gene page

Small size of the Tnnt3tm2a(KOMP)Wtsi/Tnnt3+ mice Show the 4 phenotype image(s) involving this allele.

Mutant Cell Lines:	EPD0084_2_B02, EPD0084_2_C01, EPD0084_2_C02, EPD0084_2_C04, EPD0084_2_D04, EPD0084_2_G02, EPD0084_2_G03, EPD0084_2_G04, EPD0084_2_H04
Germline Transmission:	Earliest citation of germline transmission: J:204474
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 142063935 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 142064707. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534, J:204474)

Generation of the Tnnt3tm2a(KOMP)Wtsi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Tnnt3 Mutation:	23 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	3 reference(s)