Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ldhaa-m2Neu
Name:	lactate dehydrogenase A; mutation 2, Neuherberg
MGI ID:	MGI:3776262
Synonyms:	LDH 1049, Ldh1a2Neu
Gene:	Ldha  Location: Chr7:46491698-46505051 bp, + strand  Genetic Position: Chr7, 30.6 cM
Alliance:	Ldhaa-m2Neu page

Strain of Origin:

(102/El x C3H/El)F1

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: ENU mutagenesis resulted in a nucleotide substitution at codon 112 of AAC to GAC that created an amino acid substitution of an aspartic acid for an asparagine at position 112 (N112D). This mutation occures in the coenzyme-binding domain and results in a decreased enzymatic activity to 58% of wild-type in heterozygotes. (J:45877) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldha Mutation:	34 strains or lines available

Original:	J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
All:	4 reference(s)