Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ldlrtm1(AFP)Alb
Name:	low density lipoprotein receptor; targeted mutation 1, Arthur L Beaudet
MGI ID:	MGI:3775950
Gene:	Ldlr  Location: Chr9:21634872-21661215 bp, + strand  Genetic Position: Chr9, 7.87 cM
Alliance:	Ldlrtm1(AFP)Alb page

Germline Transmission:	Earliest citation of germline transmission: J:132096
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Ldlrtm1(AFP)Alb expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human AFP (174) Afp  (MGI:87951)   Ldlrtm1(AFP)Alb expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ldlr (MGI:96765)   Mutation details: A cassette containing a splice acceptor, IRES, human AFP and a splice donor was inserted into intron 1 along with a floxed neo cassette. The neo cassette was removed by transient cre expression. Expression of AFP was confirmed by a quantitative immunoassay. (J:132096)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldlr Mutation:	76 strains or lines available

Original:	J:132096 Li K, et al., A gene fusion method to screen for regulatory effects on gene expression: application to the LDL receptor. Hum Mol Genet. 2002 Dec 15;11(26):3257-65
All:	1 reference(s)