Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rpap2tm1a(KOMP)Wtsi
Name:	RNA polymerase II associated protein 2; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID:	MGI:4362158
Gene:	Rpap2  Location: Chr5:107745239-107809704 bp, + strand  Genetic Position: Chr5, 52.23 cM
Alliance:	Rpap2tm1a(KOMP)Wtsi page
IMPC:	Rpap2 gene page

Mutant Cell Lines:	EPD0064_1_A01, EPD0064_1_C02, EPD0064_1_C03, EPD0064_1_D01, EPD0064_1_F02, EPD0064_1_F03, EPD0064_1_G02, EPD0064_1_G03, EPD0064_1_H02, EPD0064_1_H03
Germline Transmission:	Earliest citation of germline transmission: J:175295
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter) Mutation:    Insertion     Vector: L1L2_gt0   Mutation details: The L1L2_gt0 cassette was inserted at position 107754350 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 107755222. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 2 lines available
Carrying any Rpap2 Mutation:	39 strains or lines available

Original:	J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:	3 reference(s)