Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lpin120884
Name:	lipin 1; 20884
MGI ID:	MGI:4361554
Gene:	Lpin1  Location: Chr12:16585670-16696967 bp, - strand  Genetic Position: Chr12, 7.9 cM
Alliance:	Lpin120884 page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A T to A transversion is located in exon 20 resulting in a tyrosine to asparagine missense mutation (Y873N). Western blot analysis showed similar levels of protein expression in all tissues examined except adipose tissue where protein levels are about twice that of controls. In adipose tissue from homozygous mutant mice phosphatidate phosphatase type 1 activity is reduced to about 20% of controls. (J:153042) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lpin1 Mutation:	56 strains or lines available

Original:	J:153042 Douglas DS, et al., Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis. J Neurosci. 2009 Sep 30;29(39):12089-100
All:	2 reference(s)